The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional Kliqqi
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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory domain but lacked the zinc finger DNA-binding domain, and thus the truncated Ex4a(+)WT1 isoform retained the ability to interact with the transcriptional co-activators but misplaced the chance to bind to promoter of downstream targets. Past scientific studies have demonstrated which the N-terminal domai